Nick Chubb ran for 131 yards, and Mayfield finished 20 of 31 for 194 yards and a touchdown.
Cleveland’s first-quarter turnovers came on three consecutive plays. Along with the three turnovers, the Browns committed 13 turnovers.
After the Patriots took a 3-0 lead, Chubb took a handoff from Mayfield but had the ball inadvertently kicked out of his hands by left guard Joel Bitonio . It was scooped up by Dont’a Hightower and returned 26 yards for a touchdown.
On the first play of the ensuing series after the Patriots’ kickoff landed out of bounds, Chubb got the ball again, this time getting around the edge and scampering 44 yards down the sideline.
Following a Patriots’ punt, the Browns’ next series ended when Lawrence Guy broke into the backfield and stepped in front of Mayfield’s shovel pass attempt to Chubb on the Cleveland 16 for his first-career interception.
The Browns are at Denver next week