The NCAA Tournament is heading to the Sweet 16 in the battle for the national championship in men’s basketball. Top seeds Purdue and defending champion Kansas did not make it. Sweet 16 weekend will see games in New York City, Las Vegas, Kansas City, Missouri, and Louisville, Kentucky. The Final Four is in Houston. The semifinals are on April 1, with the championship game on April 3.

March Madness is heading to the Sweet 16 without a handful of top teams. Two No. 1 seeds, Kansas and Purdue, No. 2 seed Arizona and No. 4 seed Virginia are all gone — and gone with them are millions of busted brackets.

It’s been tough sledding for the bluebloods, too: Besides Kansas, Kentucky, Duke and Indiana are all heading home. UCLA’s drive for a 12th national title remains alive.

EAST REGION: The Boilermakers got a top seed for the fourth time, but Purdue was dumped by Fairleigh Dickinson in a near-historic upset. and the 2-seed, Marquette, is also gone. Up next: No. 9 seed FAU vs. No. 4 seed Tennessee and No. 3 seed Kansas State vs. No. 7 seed Michigan State, whose coach Tom Izzo is heading to his 15th regional.

SOUTH REGION: Alabama, led by coach Nate Oats in a challenging season, got a top seed for the first time behind SEC player of the year Brandon Miller, who has armed security on hand after being the subject of threats. Up next: No. 1 seed Alabama vs. No. 5 seed San Diego State and No. 6 seed Creighton vs. No. 15 seed Princeton, which is in rare territory.

MIDWEST REGION: Houston got a top seed and won its opener before a rugged victory over Auburn even with All-American Marcus Sasser hobbled by a groin injury. Up next: No. 1 seed Houston vs. No. 5 seed Miami and No. 2 seed Texas vs. No. 3 seed Xavier.

WEST REGION: Kansas, the top-seeded defending national champion that was without coach Bill Self in the tournament following a heart procedure, blew an 8-point halftime lead and lost to Arkansas. Up next: No. 2 seed UCLA vs. No. 3 Gonzaga and No. 4 seed UConn vs. No. 8 seed Arkansas.