The best pitcher in baseball this season by so many measures, Cleveland’s Shane Bieber has made so few mistakes.

Byron Buxton prepared himself for the rare occasion and sent a misplaced slider into the empty seats on the first pitch he saw.

Buxton hit a two-run homer and Kenta Maeda pitched seven shutout innings for Minnesota, as the Twins handed Bieber his first loss of the season on Friday with a 3-1 victory over the Indians.

“He’s tough. We got him tonight because we stayed focused,” said Buxton, who followed Jake Cave‘s double in the second with his seventh home run of the season. “That’s what it takes to go out there and beat one of the best pitchers in the league.”

Bieber (7-1) yielded five hits and two walks with eight strikeouts in seven innings, matching a season-most three runs allowed on the homers by Buxton and rookie Ryan Jeffers. This was the first time the right-hander was taken deep in six starts.

“It really came down to I made two mistakes,” said the 25-year-old Bieber, who’s quickly become the leader of a stout rotation that has seen Trevor BauerCorey Kluber and Mike Clevinger all traded within the last 14 months.

The hitting is another story for the Indians. They’ve scored three runs in the last 33 innings, continuing a downward trend that began last season. Francisco Lindor batted leadoff for the first time this year, but the Indians didn’t get a runner to second base until the ninth. Lindor led off the sixth with a single and was promptly picked off first base.

“I know what we can do as a team offensively. I’ve been on the wrong end of it many times,” said Bieber, whose baseball-best ERA rose from 1.32 to a mere 1.53.

Bieber still became the fastest starting pitcher since 1900 to reach 100 strikeouts in a season, hitting the milestone in 62 1/3 innings, two fewer outs than Washington’s Max Scherzer in 2018.

“He’s not going to leave a ton of pitches right in the middle of the strike zone,” Jeffers said. “So you’ve got to attack from pitch one, and I think we did a really good job of that.”

Taylor Rogers gave up a homer to Jose Ramirez in the ninth, then finished his ninth save. The Twins (28-18) improved to 8-2 in September and 19-5 at their empty home ballpark.

Minnesota stayed one game behind Chicago (28-16) in the American League Central race, pushing Cleveland (26-19) to 2 1/2 games back.

For the second time this week, the Twins played through raw, damp conditions, this time after a 42-minute rain delay. Maeda (5-1) was more than up to the task, allowing just four hits and two walks with seven strikeouts. Maeda, in his first season with Minnesota, has been no slouch, lowering his ERA to 2.43. His walks-and-hits-per-inning rate is the best in baseball.

“I’m trying to fulfill the expectations that the team has for me,” Maeda said through an interpreter. “I think I’ve been doing that pretty well.”